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Jason C. Huang


Jason C. Huang,  Ph.D.

Associate Professor

Tel: +886-2-2826-7148

   Fax: +886-2-2826-40


  Institute of Biotechnology in Medicine, National Yang-Ming University ,

 No.155, Sec.2, 

 Li-Nong Street, Taipei 112,

8/2009-present Associate Professor

8/2004-7/2009 Assistant Professor
Department of Biotechnology and Laboratory Science in Medicine
National Yang-Ming University

2/2001-7/2004 Postdoctoral research fellow
Center for Immunology
The University of Texas Southwestern Medical Center
Dallas, TX, USA

9/1994-8/2000 Ph.D.
Graduate Program in Experimental Pathology
The University of Texas Medical Branch
Galveston, TX, USA

7/1993-6/1994 Research Assistant
Institute of Microbiology
College of Medicine
National Taiwan University
Taipei, Taiwan

10/1991-5/1993 Navy Ensign & Medical Technologist
811 Armed Forces Hospital
Peng-hu, Taiwan

9/1987-6/1991 B.S.
Department of Medical Technology
National Yang-Ming University
Taipei, Taiwan

Research Interests
1. Study of some cellular genes in B cells induced by Epstein-Barr Virus infection and their roles in immortalization
2. Identification of T cell and B cell epitopes of H5N1 virus
3. Study of immune modulating agents on the treatment of autoimmune disease (multiple sclerosis) using experimental autoimmune encephalomyelitis (EAE) model
4. Study of metastasis related genes and cancer stem cells in colorectal cancer

1. Huang, J.C., Chang, Y.F., Chen, K.H., Su, L.C., Lee, C.W., Chen, C.C., Chen, Y.M., and Chou, C. Detection of severe acute respiratory syndrome (SARS) coronavirus nucleocapsid protein in human serum using a localized surface plasmon coupled fluorescence fiber-optic biosensor. Biosens Bioelectron. 2009, 25(2):320-325
2. Wang, S.F., Lee, Y.M., Chan, Y.J., Liu, H.F., Yen, Y.F., Liu, W.T., Huang, J.C*., and Chen, Y.M. Influenza A Virus in , 1980-2006:Phylogenetic and antigenic characteristics of the hemagglutinin gene. J Med Virol 2009, 81 (8):1457-1470 (*co-coresponding author)
3. Peng, S.Y., Chu, T.H., Wang, I.C., Chung, W.C., Yu, K.W., Tsaihong, J.C., Huang, J.C., and Fan, P.C. Infection of normal C3H/HeN mice with Taenia saginata asiatica oncospheres. Res Vet Sci 2009;86(2):261-266
4. Wang, S.F., Chen, K.H., Thitithanyanont, A., Yao , L., Lee, Y.M., Chan, Y.J., Liu, S.J., Chong, P., Liu, W.T., Huang, J.C.*., and Chen, Y.M. Generating and characterizing monoclonal and polyclonal antibodies against avian H5N1 hemagglutinin protein. Biochem Biophy Res Commun 2009;382(4)691-696 (*co-coresponding author)
5. Song, Y.C., Sun, G.H., Lee, T.P., Huang, J.C., Yu, C.L., Chen, C.H., Tang, S.J., Sun, K.H. Arginines in the CDR of anti-dsDNA autoantibodies facilitate cell internalization via electrostatic interactions. Eur J Immunol. 2008; 38 (11):3178-3190
6. Lee, T.P., Leu, S.J., Huang, J.C., Song,Y.C., Jhou, R.S., Tang,S.J., and Sun, K.H. Anti-ribosomal P autoantibody triggers IL-10 over-production via PI3K-dependent signaling pathways in LPS-activated macrophages. Immunology. 2008;127(7):91-102
7. Wang, S.F.*, Huang, J.C.*, Lee, Y.M., Liu, S.J., Chan, Y.J., Chau, Y.P., Chong, P., and Chen, Y.M. DC-SIGN mediates avian H5N1 influenza virus infection in cis and in trans. Biochem Biophys Res Commun. 2008.373(4):561-566, (* equal contribution)
8. Sahu, G.K., McNearney, T., Evans, A., Turner, A., Weaver, S., Huang, J.C., Baron, S., Paar, D. and Cloyd, M.W. Transient or occult HIV infection may occur more frequently than progressive infections: Changing the paradigm about HIV persistence. Arch Virol 2005;19:131-145.
9. Huang, J.C., Ober, R.J., and Ward, E.S. The central residues of a T cell receptor sequence motif are key determinants of autoantigen recognition in murine experimental autoimmune encephalomyelitis. Eur J Immunol 2005. 35(1):299-304.
10. Huang, J.C., Vestberg, M., Minguela, A., Holmdahl, R., Ward, E.S. Analysis of autoreactive T cells associated with murine collagen-induced arthritis using peptide-MHC multimers, Int Immunol 2004. 16(2):283-93.
11. Huang, J.C., Han, M., Minguela, A., Pastor, S., Qadri, A., Ward, E.S. T cell recognition of distinct peptide:I-Au conformers in murine experimental autoimmune encephalomyelitis. J Immunol 2003. 171(5):2467-77.
12. Chen, J.J., Huang J.C., Shirtliff, M., Briscoe, E., Ali, S., Cesani, F., Paar, D., Cloyd, M.W. CD4 lymphocytes in the blood of HIV(+) individuals migrate rapidly to lymph nodes and bone marrow: support for homing theory of CD4 cell depletion. J Leukoc Biol 2002. 72(2):271-8.
13. Sahu, G.K., Chen, J.J., Huang, J.C., Ramsey, K.M., Cloyd, M.W. Transient or occult HIV-1 infection in high-risk adults. AIDS. 2001.15(9):1175-7.