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Kuang-Hui Sun

 

 

NAME

  

 

 

 

Sun, Kuang-Hui

  

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POSITION TITLE/AFFILIATIONS

 

 

 

 

 

 

 

Professor, Department of Biotechnology and Laboratory Science in Medicine, National Yang-Ming University

 

 

 

 

Associate Dean, Office of Research and Development, National Yang-Ming University

EDUCATION/TRAINING

INSTITUTION AND LOCATION

DEGREE

(if applicable)

YEAR(s)

FIELD OF STUDY

Microbiology & Immunology, National Yang-Ming University

Ph.D.

1996

Autoimmune, Tumor biology

Microbiology & Immunology, National Yang-Ming University

 

Master

1986

Molecular Medicine

 

 

 

 

 

A.   Current Research (Maximum 500 words)

Molecular pathogenesis of lupus

Systemic lupus erythematosus (SLE) is a multi-organ autoimmune disease. One of the characteristics is the presence of autoantibodies against double-stranded-DNA (anti-dsDNA) in serum at high levels. In addition, bacterial infections are associated with higher morbidity and mortality in SLE. However, interaction between the risk factors in the pathogenesis of lupus remains to be determined. Furthermore, current therapies for SLE including steroids and immunosuppressive agents have more side effects. Therefore, we focus on the roles of infection (innate immunity) and anti-dsDNA in the pathogenesis of SLE. Moreover, these results may also provide molecular targets for the development of new drugs. The new therapeutic strategies may be alternatives for the classical steroid treatment for SLE.

 

 

 

 

 

Molecular tumorigenesis and novel immunotherapy of cancer

The tumor microenvironment consists of immune cells, mesenchymal-derived cells, fibroblasts, surrounding blood vessels, signaling molecules, and the extracellular matrix. It forms a complex regulatory network that fosters tumor growth by evading immune surveillance and destruction. Tumors also can influence the microenvironment by releasing extracellular signals, promoting tumor angiogenesis and inducing peripheral immune tolerance. Therefore, the tumor microenvironment
contributes to tumor initiation, tumor progression and responses to therapy. The clinical therapies of lung cancer and renal cell carcinomas (RCC) are based on combined chemotherapy or molecular targeting therapy. However, the overall survival rate has improved only marginally and the relapse rate is high. Defining the factors involved in the tumor microenvironment for disease progression and metastasis will provide molecular targets for the development of effective therapies. Therefore, we focus on the molecules of tumor microenvironment in the cancer progression, including galectin family, proinflammatory cytokines, chemokines and receptors. In addition, we develop cancer immunotherapy.

 

 

 

 

 

 

B.   Positions and Honors.

 

 

 

Positions and Employment

  • Associate Dean, Office of Research and Development, National Yang-Ming University (2011-present)

     

  • Professor, Department of Biotechnology and Laboratory Science in Medicine, National Yang-Ming University (2002-present)

     

  • Chairman, Department of Biotechnology and Laboratory Science in Medicine, National Yang-Ming University (2002-2008)

     

  • Associate Professor, Faculty of Medical Technology, National Yang-Ming University (1996-2002)

     

  • Instructor, Faculty of Medical Technology, National Yang-Ming University (1989-1996)

     

  • Medical Technologist, Taipei Veterans General Hospital (1986-1989)

     

Honors, Prizes, Awards

2013

 

 

 

 

 

 

 

Academic Award from the Taiwan Society of Laboratory Medicine

 

 

 

 

 

 

 

2010

 

 

 

 

 

 

 

Outstanding Researcher Award from the Chinese Society of Immunology

 

 

 

 

 

 

 

2010

 

 

 

 

 

 

 

Academic Award from the Taiwan Society of Laboratory Medicine

 

 

 

 

 

 

 

2009

 

 

 

 

 

 

 

Best Paper Award from Shui-Teh Shen Culture and Education Foundation

 

 

 

 

 

 

 

2007

 

 

 

 

 

 

 

Academic Award from the Taiwan Society of Laboratory Medicine

 

 

 

 

 

 

 

2005

 

 

 

 

 

 

 

Outstanding Medical Researcher Award from Shu-Chi Chuang Memorial Foundation

 

 

 

 

 

 

 

 

 

 

 

 

 

 

C.   Selected Publications in the past 5 years

 

 

 

 

 

1.        Huang CS, Tang SJ, Chung LY, Yu CP, Ho JY, Cha TL, Hsieh CC, Wang HH, Sun GH, Sun KH*. Galectin-1 upregulates CXCR4 to promote tumor progression and poor outcome in kidney cancer. J Am Soc Nephrol. 2014 Jul;25(7):1486-95.

 

 

 

2.        Lee TP, Huang JC, Liu CJ, Chen HJ, Chen YH, Tsai YT, Yang W, Sun KH*.  Interactions of surface-expressed TLR-4 and endosomal TLR-9 accelerate lupus progression in anti-dsDNA antibody transgenic mice. Exp Biol Med. 2014 Apr 9;239(6):715-723. (Featured Article)

 

3.        Cha TL, Chuang MJ, Tang SH, Wu ST, Sun KH, Chen TT, Sun GH, Chang SY, Yu CP, Ho JY, Liu SY, Huang SM, Yu DS. Emodin modulates epigenetic modifications and suppresses bladder carcinoma cell growth. Mol Carcinog. 2013 Sep 20. doi: 10.1002/mc.22084. [Epub ahead of print] 

 

4.        Chuang MJ, Wu ST, Tang SH, Lai XM, Lai HC, Hsu KH, Sun KH, Sun GH, Chang SY, Yu DS, Hsiao PW, Huang SM, Cha TL. The HDAC Inhibitor LBH589 Induces ERK-Dependent Prometaphase Arrest in Prostate Cancer via HDAC6 Inactivation and Down-Regulation. PLoS One. 2013 Sep 4;8(9):e73401.

 

5.        Chiu HY, Sun GH, Chen SY, Wang HH, Ho MY, Chu CY, Wu WL, Jhou RS, Tsai YL, Huang RT, Sun KH*, Tang SJ*. Pre-existing Fas ligand (FasL) in cancer cells elicits tumor-specific protective immunity, but delayed induction of FasL expression after inoculation facilitates tumor formation. Mol Carcinog. 2013 Sep;52(9):705-14.  (*: corresponding author)

 

6.        Hsu HL, Huang HH, Liang CC, Lin HC, Liu WT, Lin FP, Kau JH*, Sun KH*. Suspension bead array of the single-stranded multiplex polymerase chain reaction amplicons for enhanced identification and quantification of multiple pathogens. Anal Chem. 2013 Jun 4;85(11):5562-8. (*: corresponding author)

 

7.        Chung LY, Tang SJ, Sun GH, Chou TY, Yeh TS, Yu SL, Sun KH*. Galectin-1 promotes lung cancer progression and chemoresistance by upregulating p38 MAPK, ERK, and cyclooxygenase-2. Clin Cancer Res. 2012 Aug 1;18(15):4037-47. (*: corresponding author)

 

 

 

8.        Chiu HY, Sun KH, Chen SY, Wang HH, Lee MY, Tsou YC, Jwo SC, Sun GH, Tang SJ. Autocrine CCL2 promotes cell migration and invasion via PKC activation and tyrosine phosphorylation of paxillin in bladder cancer cells. Cytokine. 2012 Aug;59(2):423-32.

 

 

 

9.        Ho MY, Tang SJ, Chuang MJ, Cha TL, Li JY, Sun GH*, Sun KH*. TNF-α induces epithelial-mesenchymal transition of renal cell carcinoma cells via a GSK3β-dependent mechanism. Mol Cancer Res. 2012 Aug;10(8):1109-19.  (*: corresponding author)

 

 

 

10.     Wu ST, Sun GH, Hsu CY, Huang CS, Wu YH, Wang HH, Sun KH*.Tumor necrosis factor-α induces epithelial-mesenchymal transition of renal cell carcinoma cells via a nuclear factor kappa B-independent mechanism. Exp Biol Med (Maywood). 2011 Sep;236(9):1022-9  (*: corresponding author)

 

 

 

11.     Hung KS, Liu SM, Fang TY, Tzou WS, Lin FP, Sun KH, Tang SJ. Characterization of a salt-tolerant xylanase from Thermoanaerobacterium saccharolyticum NTOU1. Biotechnol Lett. 2011 Jul;33(7):1441-7.

 

 

 

12.     Hung KS, Chen SY, Liu HF, Tsai BR, Chen HW, Huang CY, Liao JL, Sun KH, Tang SJ. C-terminal region of Candida rugosa lipases affects enzyme activity and interfacial activation. J Agric Food Chem. 2011 May 25;59(10):5396-401.

 

13.     Lee CW, Leu SJ, Tzeng RY, Wang SF, Tsai SC, Sun KH, Chen RH, Huang JC. Latent membrane protein 1 of Epstein-Barr virus regulates death-associated protein kinase 1 in lymphoblastoid cell line. Virology. 2011 Apr 25;413(1):19-25.

 

14.     Ho MY, Tang SJ, Sun KH, Yang W. Immunotherapy for lung cancers. J Biomed Biotechnol. 2011;2011:250860.( Review Article)

 

 

 

15.     Chang YI, Lin SW, Chiou YY, Sung JS, Cheng LC, Lu YL, Sun KH, Chang K, Lin CH, Lin WJ. Establishment of an ectopically expressed and functional PRMT1 for proteomic analysis of arginine-methylated proteins. Electrophoresis. 2010 Dec;31(23-24):3834-42.

 

 

 

16.     Lee TP, Tang SJ, Wu MF, Song YC, Yu CL, Sun KH*. Transgenic overexpression of anti-double-stranded DNA autoantibody and activation of Toll-like receptor 4 in mice induce severe systemic lupus erythematosus syndromes. J Autoimmun. 2010 Dec;35(4):358-67.  (*: corresponding author)

 

 

 

17.     Ho MY, Tang SJ, Ng WV, Yang W, Leu SJ, Lin YC, Feng CK, Sung JS*, Sun KH*. Nucleotide-binding domain of phosphoglycerate kinase 1 reduces tumor growth by suppressing COX-2 expression. Cancer Sci. 2010 Nov;101(11):2411-6.  (*: corresponding author)

 

18.     Song YC, Tang SJ, Lee TP, Hung WC, Lin SC, Tsai CY, Ng WV, Wu MF, Sun KH*. Reversing interleukin-2 inhibition mediated by anti-double-stranded DNA autoantibody ameliorates glomerulonephritis in MRL-lpr/lpr mice. Arthritis Rheum. 2010 Aug;62(8):2401-11.  (*: corresponding author)

 

19.     Ho MY, Leu SJ, Sun GH, Tao MH, Tang SJ, Sun KH*. IL-27 directly restrains lung tumorigenicity by suppressing cyclooxygenase-2-mediated activities. J Immunol. 2009 Nov 15;183(10):6217-26.  (*: corresponding author)

 

 

 

20.     Lee HT, Chen WS, Sun KH, Chou CT, Tsai CY. Increased spontaneous but decreased mitogen-stimulated expression and excretion of interleukin 18 by mononuclear cells in patients with active systemic lupus erythematosus. J Rheumatol. 2009 Sep;36(9):1910-6. 

 

 

 

21.     Lee TP, Leu SJ, Huang JC, Song YC, Jhou RS, Tang SJ, Sun KH*. Anti-ribosomal phosphoprotein autoantibody triggers interleukin-10 overproduction via phosphatidylinositol 3-kinase-dependent signalling pathways in lipopolysaccharide-activated macrophages. Immunology. 2009 May;127(1):91-102.  (*: corresponding author)

 

 

 

22.     Jhou RS, Sun KH, Sun GH, Wang HH, Chang CI, Huang HC, Lu SY, Tang SJ. Inhibition of cyclin-dependent kinases by olomoucine and roscovitine reduces lipopolysaccharide-induced inflammatory responses via down-regulation of nuclear factor kappaB. Cell Prolif. 2009 Apr;42(2):141-9.

 

23.     Tang SJ, Ho MY, Cho HC, Lin YC, Sun GH, Chi KH, Wang YS, Jhou RS, Yang W, Sun KH. Phosphoglycerate kinase 1-overexpressing lung cancer cells reduce cyclooxygenase 2 expression and promote anti-tumor immunity in vivo. Int J Cancer. 2008 Dec 15;123(12):2840-8.  (*: corresponding author)

 

 

 

24.     Li HH, Cheng HH, Sun KH, Wei CC, Li CF, Chen WC, Wu WM, Chang MS. Interleukin-20 targets renal mesangial cells and is associated with lupus nephritis. Clin Immunol. 2008 Nov;129(2):277-85.

 

25.     Song YC, Sun GH, Lee TP, Huang JC, Yu CL, Chen CH, Tang SJ, Sun KH*. Arginines in the CDR of anti-dsDNA autoantibodies facilitate cell internalization via electrostatic interactions. Eur J Immunol. 2008 Nov;38(11):3178-90. (*: corresponding author)

 

26.     Ho MY, Sun GH, Leu SJ, Ka SM, Tang SJ, Sun KH*. Combination of Fasl and GM-CSF confers synergistic antitumor immunity in an in vivo model of the murine Lewis lung carcinoma. Int J Cancer. 2008 Jul 1;123(1):123-33. (*: corresponding author)

 

27.     Chuang MJ, Sun KH, Tang SJ, Deng MW, Wu YH, Sung JS, Cha TL, Sun GH. Tumor-derived tumor necrosis factor-alpha promotes progression and epithelial-mesenchymal transition in renal cell carcinoma cells. Cancer Sci. 2008 May;99(5):905-13.